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Overview of dual-acting drug methotrexate in different neurological diseases, autoimmune pathologies and cancers

Huang et al., 2014)

In addition, the accumulation of acylcarnitine in the pathological state of the liver leads to insulin resistance, which further aggravates the development of liver diseases and results in a vicious cycle [211]

3.1 Biological Interpretation of GSH and GSSG Concentrations A decrease in GSH can result from reduced synthesis, oxidation, conjugation, protein S-glutathionylation, export, degradation, or loss of cellular integrity